Article

DNA Nicks Drive Massive Expansions of (GAA) <sub>n</sub> Repeats

2024-06-12

Abstract excerpt

Over 50 hereditary degenerative disorders are caused by expansions of short tandem DNA repeats (STRs). (GAA) n repeat expansions are responsible for Friedreich’s ataxia as well as late-onset cerebellar ataxias (LOCAs). Thus, the mechanisms of (GAA) n repeat expansions attract broad scientific attention. To investigate the role of DNA nicks in this process, we utilized a CRISPR-Cas9 nickase system to introduce ta...

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Literature Corpus work: 367f685b-7247-5caf-8615-b35d0031d011
DOI: 10.1101/2024.06.12.598717

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