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A multi-omics analysis of human fibroblasts overexpressing an <i>Alu</i> transposon reveals widespread disruptions in aging-associated pathways

2025-07-17

Abstract excerpt

<h4>ABSTRACT</h4> During aging and cellular senescence, repetitive elements are frequently transcriptionally derepressed across species and cell types. Among these, the most abundant repeats by copy number in the human genome are Alu retrotransposons. Though Alu elements are often studied for their mutagenic potential, there is increasing appreciation for their contributions to other biological functions, inclu...

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Identifiers and source

Literature Corpus work
62f94482-36c6-5a39-99c9-fee3b8fa750e
DOI
10.1101/2025.07.11.664466
Open publication

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A multi-omics analysis of human fibroblasts overexpressing an <i>Alu</i> transposon reveals widespread disruptions in aging-associated pathwaysDOI 10.1101/2025.07.11.664466
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