Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensing soluble uric acid by Naip1-Nlrp3 platform

5 Feb 2021

Abstract excerpt

Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. Despite being inert in human cells, UA in its soluble form (sUA) can increase the level of interleukin-1β (IL-1β) in murine macrophages. We, therefore, hypothesized that the recognition of sUA is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gout, Hyperuricemia, Uric Acid
Share to Immune Cell Function and Interaction
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33547278
DOI: 10.1038/s41419-021-03445-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensing soluble uric acid by Naip1-Nlrp3 platformPMID 33547278Read ↗

Sensing soluble uric acid by Naip1-Nlrp3 platformSemantic proximity Read ↗

Human NLRP1: From the shadows to center stageSemantic proximity Read ↗

The Role of Uric Acid in Human Health: Insights from the Uricase GeneSemantic proximity Read ↗

Hyperuricemia and its related diseases: mechanisms and advances in therapySemantic proximity Read ↗

Gout: one year in review 2026.Semantic proximity Read ↗

Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations.Semantic proximity Read ↗

[Gout - from pathogenesis to treatment - progress in the XXI century].Semantic proximity Read ↗

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.Semantic proximity Read ↗

Human NLRP1 and NLRP3 interact to drive inflammation in inflammosomopathies and inflammatory diseasesSemantic proximity Read ↗

New Potentiality of Bioactive Substances: Regulating the NLRP3 Inflammasome in Autoimmune DiseasesSemantic proximity Read ↗

The current role of NLRP3 inflammasome polymorphism in gout susceptibility.Semantic proximity Read ↗

Crystal ball gazing: new therapeutic targets for hyperuricaemia and goutSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.