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Article

The inflammasome, autoinflammatory diseases, and gout.

Joint bone spine - 1 Dec 2007

Pétrilli Virginie, Martinon Fabio

Abstract excerpt

IL-1beta is a cytokine with major roles in inflammation and innate immune responses. IL-1beta is produced as an inactive proform that must be cleaved within the cell to generate biologically active IL-1beta. The enzyme caspase-1 catalyzes the reaction. Recent work showed that caspase-1 must be activated by a complex known as the inflammasome. The inflammasome comprises NALP, which is an intracellular receptor...

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Identifiers

PMID: 17714972
DOI: 10.1016/j.jbspin.2007.04.004

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