Article

Influenza B virus suppression of Chromosome Y-linked genes increases pulmonary virus replication and disease severity in male mice

2026-03-24

Abstract excerpt

<title>Abstract</title> <p>Influenza B viruses (IBV) are transmitted among humans, with disease being worse in men than women. C57BL/6 male and female mice were inoculated with Victoria lineage B/Brisbane/60/2008 containing a PB2 F406Y mutation. Juvenile, adult, and aged males exhibited greater virus titers, morbidity, and pulmonary inflammation than age-matched females. Oseltamivir treatment reduced virus titers...

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Literature Corpus work: 35f2043e-f7a9-5ed1-a741-102bb8d096d4
DOI: 10.21203/rs.3.rs-9066058/v1

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