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Article

Sex chromosome complement contributes to sex differences in coxsackievirus B3 but not influenza A virus pathogenesis

1 Jan 2011

Abstract excerpt

BACKGROUND: Both coxsackievirus B3 (CVB3) and influenza A virus (IAV; H1N1) produce sexually dimorphic infections in C57BL/6 mice. Gonadal steroids can modulate sex differences in response to both viruses. Here, the effect of sex chromosomal complement in response to viral infection was evaluated using four core genotypes (FCG) mice, where the Sry gene is deleted from the Y chromosome, and in some mice is...

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PMID: 21806829
DOI: 10.1186/2042-6410-2-8

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