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Article

Evidence that the Y chromosome influences autoimmune disease in male and female mice.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 2006

Teuscher Cory, Noubade Rajkumar, Spach Karen, McElvany Benjamin, Bunn Janice Y, Fillmore Parley D, Zachary James F, Blankenhorn Elizabeth P

Abstract excerpt

Experimental allergic encephalomyelitis (EAE), an autoimmune model of multiple sclerosis, is a complex disease influenced by genetic, intrinsic, and environmental factors. In this study, we questioned whether parent-of-origin effects influence EAE, using reciprocal F2 intercross progeny generated between EAE-susceptible SJL/J (S) and EAE-resistant B10.S/SgMcdJ (B) mice. EAE susceptibility and severity were found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crosses, Genetic

Share to Encephalomyelitis, Autoimmune, Experimental

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Source

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Identifiers

PMID: 16702550
DOI: 10.1073/pnas.0600536103
PMCID: PMC1472423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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