The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum.

Abstract excerpt

Heart failure (HF) remains a major cause of mortality and morbidity worldwide. Understanding the genetic basis of HF allows for the development of disease-modifying therapies, more appropriate risk stratification, and personalised management of patients. The advent of next-generation sequencing has enabled genome-wide association studies; moving beyond rare variants identified in a Mendelian fashion and detecting...

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