Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide analysis of cardiac ventricular phenotypes reveals novel loci and therapeutic targets for heart failure.

Nature communications - 27 Feb 2026

Nicholls Hannah L, Vargas Jose D, Sanghvi Mihir M, Ahn Hyo-Suk, Chahal C Anwar A, Khanji Mohammed Y, Petersen Steffen E, Munroe Patricia B, Aung Nay

Abstract excerpt

Left and right ventricular imaging measures are essential for heart failure diagnosis and prognostication, yet their genetic architecture remains underexplored. We conduct genome-wide association analyses of twenty left and right cardiovascular magnetic resonance phenotypes in 56,509 UK Biobank participants, including conventional measurements (e.g., volumes/ejection fraction) and novel parameters (left...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic Nucleotide Phosphodiesterases, Type 3
Share to Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Risk Score

Share to Genome-Wide Association Study

Share to Heart Failure

Share to Heart Ventricles

Share to Magnetic Resonance Imaging

Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 41760662
DOI: 10.1038/s41467-026-69982-0
PMCID: PMC13066029

Genes

ALDH2
CAMK2D
ENG
HSPB7
PDE3A
YWHAE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis of cardiac ventricular phenotypes reveals novel loci and therapeutic targets for heart failure.PMID 41760662Read ↗

Analysis of cardiac magnetic resonance imaging traits in 29,000 individuals reveals shared genetic basis with dilated cardiomyopathySemantic proximity Read ↗

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.Semantic proximity Read ↗

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart FailureSemantic proximity Read ↗

Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.Semantic proximity Read ↗

Cardiac magnetic resonance markers of pre-clinical hypertrophic and dilated cardiomyopathy in genetic variant carriersSemantic proximity Read ↗

Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated With Cardiac Morphogenesis and Heart Failure DevelopmentSemantic proximity Read ↗

Genetics of common forms of heart failure.Semantic proximity Read ↗

Genetic architecture of heart failure with preserved versus reduced ejection fractionSemantic proximity Read ↗

Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.Semantic proximity Read ↗

Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy.Semantic proximity Read ↗

Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathySemantic proximity Read ↗

Genome-wide association analysis reveals insights into the molecular etiology underlying dilated cardiomyopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.