Article
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.
Nature genetics - 1 Apr 2025
Lee David S M, Cardone Kathleen M, Zhang David Y, Tsao Noah L, Abramowitz Sarah, Sharma Pranav, DePaolo John S, Conery Mitchell, Aragam Krishna G, Biddinger Kiran, Dikilitas Ozan, Hoffman-Andrews Lily, Judy Renae L, Khan Atlas, Kullo Iftikhar J, Puckelwartz Megan J, Reza Nosheen, Satterfield Benjamin A, Singhal Pankhuri, Arany Zoltan, Cappola Thomas P, Carruth Eric D, Day Sharlene M, Do Ron, Haggerty Christopher M, Joseph Jacob, McNally Elizabeth M, Nadkarni Girish, Owens Anjali T, Rader Daniel J, Ritchie Marylyn D, Sun Yan V, Voight Benjamin F, Levin Michael G, Damrauer Scott M
Abstract excerpt
Heart failure is a complex trait, influenced by environmental and genetic factors, affecting over 30 million individuals worldwide. Here we report common-variant and rare-variant association studies of all-cause heart failure and examine how different classes of genetic variation impact its heritability. We identify 176 common-variant risk loci at genome-wide significance in 2,358,556 individuals and cluster...
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