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Article

FIGNL1-containing protein complex is required for efficient homologous recombination repair.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 2013

Yuan Jingsong, Chen Junjie

Abstract excerpt

The RAD51 recombinase plays a central role in homologous recombination (HR), which is critical for repair of DNA double-strand breaks, maintenance of genomic stability, and prevention of developmental disorders and cancer. Here, we report the identification of an RAD51-binding protein fidgetin-like 1 (FIGNL1). FIGNL1 specifically interacts with RAD51 through its conserved RAD51 binding domain. Cells depleted of...

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Identifiers

PMID: 23754376
DOI: 10.1073/pnas.1220662110
PMCID: PMC3696823

Genes

FIGNL1
RAD51
SPIDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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