Article

Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response

2026-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Human cone and rod outer segments exhibit a rapid shrinkage followed by a slower elongation in response to light, forming the basis of the optoretinogram. The molecular basis of this optical assay of photoreceptor function remains incompletely understood. In mouse rods, the elongation response requires transducin, the G-protein α-subunit activated in the initial amplifying step of the phototrans...

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Literature Corpus work: 35b91cb8-f306-5cf2-9b32-4d5fc56fb45d
DOI: 10.64898/2026.04.28.721497

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