Optoretinography in R9AP-Bradyopsia Reveals an Essential Role of G-Protein Activation and Deactivation in the Human Cone Elongation Response.

doi:10.1523/JNEUROSCI.0736-26.2026

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Optoretinography in R9AP-Bradyopsia Reveals an Essential Role of G-Protein Activation and Deactivation in the Human Cone Elongation Response.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Sept 2026

Weiss Connor, Liu Teng, Pandiyan Vimal P, Cao Yan, Mustafi Debarshi, Carroll Joseph, Martemyanov Kirill A, Pugh Edward N, Sabesan Ramkumar

Abstract excerpt

Photoreceptor outer segments (OS) shorten and elongate in response to bleaching stimuli: these responses are measurable optically at nanometer scale resolution with OCT and collectively known as the optoretinogram (ORG). The molecular mechanisms underlying the ORG remain unresolved. Here we examine the role of G-protein in cone elongation by measuring ORGs in two female subjects with bradyopsia caused by mutation...

Read the complete abstract on PubMed

Topics

Humans
Female
Retinal Cone Photoreceptor Cells
GTP-Binding Proteins
Photic Stimulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

RGS Proteins

Electroretinography

Mutation

Male

Rhodopsin

Adult

Membrane Proteins

Adaptor Proteins, Signal Transducing

Source

Open in PubMed Open full text

Identifiers

PMID: 42532840
DOI: 10.1523/JNEUROSCI.0736-26.2026
PMCID: PMC13540608

Genes

RGS9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Optoretinography in R9AP-Bradyopsia Reveals an Essential Role of G-Protein Activation and Deactivation in the Human Cone Elongation Response.PMID 42532840Read ↗

Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation responseSemantic proximity Read ↗

Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.Semantic proximity Read ↗

Human photoreceptor outer segments shorten during light adaptation.Semantic proximity Read ↗

Six patients with bradyopsia (slow vision): clinical features and course of the disease.Semantic proximity Read ↗

Targeting individual GPCRs with redesigned nonvisual arrestins.Semantic proximity Read ↗

Ectopic expression of two cone opsins in mouse RGCs results in opposite responses to light stimulation, likely due to differential G protein activationSemantic proximity Read ↗

Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells.Semantic proximity Read ↗

RGS7 and -11 complexes accelerate the ON-bipolar cell light response.Semantic proximity Read ↗

Retest-Reliability of Cone and Rod Function Assessments in Pseudoxanthoma elasticum: PROPXE Study Report 3Semantic proximity Read ↗

Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.Semantic proximity Read ↗

Cone deactivation kinetics and GRK1/GRK7 expression in enhanced S cone syndrome caused by mutations in NR2E3.Semantic proximity Read ↗

Visual consequences of molecular changes in the guanylate cyclase-activating protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.