Article
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.
Nature - 1 Jan 2004
Nishiguchi Koji M, Sandberg Michael A, Kooijman Aart C, Martemyanov Kirill A, Pott Jan W R, Hagstrom Stephanie A, Arshavsky Vadim Y, Berson Eliot L, Dryja Thaddeus P
Abstract excerpt
The RGS proteins are GTPase activating proteins that accelerate the deactivation of G proteins in a variety of signalling pathways in eukaryotes. RGS9 deactivates the G proteins (transducins) in the rod and cone phototransduction cascades. It is anchored to photoreceptor membranes by the transmembrane protein R9AP (RGS9 anchor protein), which enhances RGS9 activity up to 70-fold. If RGS9 is absent or unable to...
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