Article
Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.
Investigative ophthalmology & visual science - 29 Aug 2011
Sakurai Keisuke, Young Joyce E, Kefalov Vladimir J, Khani Shahrokh C
Abstract excerpt
PURPOSE: Rod photoreceptors are exquisitely sensitive light detectors that function in dim light. The timely inactivation of their light responses is critical for the ability of rods to reliably detect and count photons. A key step in the inactivation of the rod transduction is the phosphorylation of the rod visual pigment, rhodopsin, catalyzed by G-protein-dependent receptor kinase 1 (GRK1). Absence of GRK1...
Topics
- Adaptation, Ocular
- Animals
- Dark Adaptation
- G-Protein-Coupled Receptor Kinase 1
- Gene Expression Regulation
- Genotype
- Light Signal Transduction
- Mice
- Mice, Transgenic
- Photic Stimulation