Article

Downregulation of Transducin Delays Photoreceptor Degeneration in P23H Rhodopsin Retinitis Pigmentosa

2025-10-05

Abstract excerpt

<h4>ABSTRACT</h4> In inherited blinding diseases, such as Retinitis Pigmentosa (RP), photoreceptors progressively degenerate, eventually leading to blindness. Unfortunately, effective treatments to prevent or delay vision loss do not exist for most RPs. Dark rearing is known to delay retinal degeneration in preclinical models of RP. Therefore, in this study we evaluated the impact of reducing photoreceptor light...

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Literature Corpus work: 191c5777-5195-5ef0-ab6f-f06727c46ff1
DOI: 10.1101/2025.10.04.680427

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