Article
Higher order interactions: detection of epistasis using machine learning and evolutionary computation.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Nelson Ronald M, Kierczak Marcin, Carlborg Orjan
Abstract excerpt
Higher order interactions are known to affect many different phenotypic traits. The advent of large-scale genotyping has, however, shown that finding interactions is not a trivial task. Classical genome-wide association studies (GWAS) are a useful starting point for unraveling the genetic architecture of a phenotypic trait. However, to move beyond the additive model we need new analysis tools specifically...
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