Article

Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis

2025-09-25

Abstract excerpt

<h4>Background</h4> Deep vein thrombosis (DVT) is a common clinical problem characterized by the formation of blood clots in deep veins. The contribution of venous smooth muscle cells (SMCs) to the onset of DVT, particularly the mechanisms driving their phenotypic changes, remains poorly understood. <h4>Methods</h4> We employed a murine stasis model of DVT via inferior vena cava (IVC) ligation in both male and f...

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Literature Corpus work: afb6a23a-1f85-5972-930d-903f186e4076
DOI: 10.1101/2025.09.24.678378

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