Article

Reversal of splicing infidelity is a pre-activation step in B cell differentiation

2022-05-13

Abstract excerpt

B cell activation and differentiation is central to the adaptive immune response. Changes in exon usage can have major impacts on cellular signaling and differentiation but have not been systematically explored in differentiating B cells. We analyzed exon usage and intron retention in RNA-Seq data from subsets of human B cells at various stages of differentiation, and in an in vitro laboratory model of B cell act...

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Literature Corpus work: 357ccf0f-c987-5d7d-9a7d-e0c05daae8a2
DOI: 10.1101/2022.05.13.491723

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