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Article

The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation

22 Dec 2015

Abstract excerpt

Alternative splicing of pre-mRNA helps to enhance the genetic diversity within mammalian cells by increasing the number of protein isoforms that can be generated from one gene product. This provides a great deal of flexibility to the host cell to alter protein function, but when dysregulation in splicing occurs this can have important impact on health and disease. Alternative splicing is widely used in the...

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PMID: 26703587
DOI: 10.3390/ijms17010003

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