Article

Aberrant splicing in B-cell acute lymphoblastic leukemia

2017-11-30

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant splicing is a hallmark of leukemias with mutations in splicing factor (SF)-encoding genes. Here we investigated its prevalence in pediatric B-cell acute lymphoblastic leukemias (B-ALL), where SFs are not mutated. By comparing them to normal pro-B cells, we found thousands of aberrant local splice variations (LSVs) per sample, with 279 LSVs in 241 genes present in every comparison. These...

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Literature Corpus work: c525015f-2999-5eb1-8679-b161d8d2f489
DOI: 10.1101/225136

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