Article

NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

2023-02-17

Abstract excerpt

<h4>Summary</h4> During postnatal development the DNA methyltransferase DNMT3A deposits high levels of non-CG cytosine methylation in neurons. This unique methylation is critical for transcriptional regulation in the mature mammalian brain, and loss of this mark is implicated in DNMT3A-associated neurodevelopmental disorders (NDDs). The mechanisms determining genomic non-CG methylation profiles are not well defin...

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Literature Corpus work: 44a2aa52-de88-5e32-aba5-474084af139e
DOI: 10.1101/2023.02.17.528965

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