Article

NSD1 governs H3K36me2-mediated DNA methylation and drives differentiation of human iPSCs by regulating ‘HIDEN’ lncRNA expression

2025-06-18

Abstract excerpt

<h4>Summary</h4> Epigenetic regulatory mechanisms, which include histone modifications and DNA methylation, play a central role in development and aging. Dimethylation of H3K36, deposited mainly by the histone methyltransferase NSD1, occurs predominantly in intergenic regions and recruits the DNA methyltransferase DNMT3A to facilitate DNA methylation. Haploinsufficiency of NSD1 results in the overgrowth disorder...

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Literature Corpus work: 0b6e632d-0a4a-54f2-a7dd-9d2d587f01cb
DOI: 10.1101/2025.06.16.659867

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