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Article

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

Nature cell biology - 1 Jul 2007

Wang Gang G, Cai Ling, Pasillas Martina P, Kamps Mark P

Abstract excerpt

Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, multiple myeloma and lung cancers. In AML, the recurring t(5;11)(q35;p15.5) translocation fuses NSD1 to nucleoporin-98 (NUP98). Here, we present the...

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Topics

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Share to Acetylation
Share to Histone-Lysine N-Methyltransferase
Share to Histone Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Myeloid Progenitor Cells

Share to Nuclear Pore Complex Proteins

Share to Oncogene Proteins, Fusion

Share to Spectrophotometry, Atomic

Source

Identifiers

PMID: 17589499
DOI: 10.1038/ncb1608

Genes

NSD1
NUP98
NSD2
NSD3
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.PMID 17589499Read ↗

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression patternSemantic proximity Read ↗

Identification of NUP98-NSD1 interactors and their implication in acute myeloid leukemiaSemantic proximity Read ↗

A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemiaSemantic proximity Read ↗

NUP98::NSD1 and FLT3-ITD collaborate to generate acute myeloid leukemiaSemantic proximity Read ↗

NUP98 ‐ NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemiaSemantic proximity Read ↗

NUP98 Rearrangements in AML: Molecular Mechanisms and Clinical ImplicationsSemantic proximity Read ↗

NUP98 rearrangements in adult AML patients: evaluation of clinical implications and identification of novel fusion partners.Semantic proximity Read ↗

The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.Semantic proximity Read ↗

NUP98 dysregulation in myeloid leukemogenesis.Semantic proximity Read ↗

NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis.Semantic proximity Read ↗

Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion GenesSemantic proximity Read ↗

Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axisSemantic proximity Read ↗

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