Article

LongPhase-S: purity estimation and variant recalibration with somatic haplotying for long-read sequencing

2025-11-24

Abstract excerpt

Accurate detection of somatic variants is crucial for precision oncology, and long-read sequencing offers unprecedented advantages in resolving complex cancer genomes. However, most long-read somatic callers rely on phasing built for a diploid genome, an assumption violated by various contamination, subclonal heterogeneity, and aneuploidy in tumors. We present LongPhase-S, a novel method that jointly reconstructs...

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Literature Corpus work: 35617d43-38ef-534a-bdc3-dbd77a8e2fb6
DOI: 10.1101/2025.11.20.689492

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