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Article

PurityEst: estimating purity of human tumor samples using next-generation sequencing data.

Bioinformatics (Oxford, England) - 1 Sept 2012

Su Xiaoping, Zhang Li, Zhang Jianping, Meric-Bernstam Funda, Weinstein John N

Abstract excerpt

UNLABELLED: We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutations in a human tumor sample with a matched normal tissue using next-generation sequencing data. We applied our tool to a whole cancer genome sequencing datasets and demonstrated the accuracy of PurityEst compared with DNA copy number-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22743227
DOI: 10.1093/bioinformatics/bts365
PMCID: PMC3426843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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