Article

ClairS-TO: A deep-learning method for long-read tumor-only somatic small variant calling

2025-03-13

Abstract excerpt

Accurate identification of somatic variants in tumor is crucial but challenging, and typically requires a matched normal sample for reliable detection, which is often unavailable in real-world research and clinical scenarios, necessitating proficient algorithms to tell real somatic variants from germline variants and background noises. However, existing tumor-only somatic variant callers that were designed for sho...

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Literature Corpus work: 71f08082-0f32-579e-b617-ab57398f69ec
DOI: 10.1101/2025.03.10.642523

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