Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strelka2: fast and accurate calling of germline and somatic variants.

Nature methods - 1 Aug 2018

Kim Sangtae, Scheffler Konrad, Halpern Aaron L, Bekritsky Mitchell A, Noh Eunho, Källberg Morten, Chen Xiaoyu, Kim Yeonbin, Beyter Doruk, Krusche Peter, Saunders Christopher T

Abstract excerpt

We describe Strelka2 ( https://github.com/Illumina/strelka ), an open-source small-variant-calling method for research and clinical germline and somatic sequencing applications. Strelka2 introduces a novel mixture-model-based estimation of insertion/deletion error parameters from each sample, an efficient tiered haplotype-modeling strategy, and a normal sample contamination model to improve liquid tumor analysis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to INDEL Mutation

Share to Models, Genetic

Share to Neoplasms

Share to Software

Share to Whole Genome Sequencing

Source

Identifiers

PMID: 30013048
DOI: 10.1038/s41592-018-0051-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strelka2: fast and accurate calling of germline and somatic variants.PMID 30013048Read ↗

Strelka2: Fast and accurate variant calling for clinical sequencing applicationsSemantic proximity Read ↗

Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs.Semantic proximity Read ↗

Somatic small-variant calling methods in Illumina DRAGEN™ Secondary AnalysisSemantic proximity Read ↗

TNscope: Accurate Detection of Somatic Mutations with Haplotype-based Variant Candidate Detection and Machine Learning FilteringSemantic proximity Read ↗

LoLoPicker: Detecting Low Allelic-Fraction Variants in Low-Quality Cancer SamplesSemantic proximity Read ↗

Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graphs.Semantic proximity Read ↗

Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graphsSemantic proximity Read ↗

ClairS-TO: A deep-learning method for long-read tumor-only somatic small variant callingSemantic proximity Read ↗

Needlestack: an ultra-sensitive variant caller for multi-sample next generation sequencing dataSemantic proximity Read ↗

ClairS: a deep-learning method for long-read tumor-normal pair somatic small variant calling.Semantic proximity Read ↗

LongPhase-S: purity estimation and variant recalibration with somatic haplotying for long-read sequencingSemantic proximity Read ↗

SNVSniffer: an integrated caller for germline and somatic single-nucleotide and indel mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.