Article

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

2021-10-11

Abstract excerpt

DNA:DNA:RNA triplexes that are formed through Hoogsteen base-pairing have been observed in vitro , but the extent to which these interactions occur in cells and how they impact cellular functions remains elusive. Using a combination of bioinformatic techniques, RNA/DNA pulldown and biophysical studies, we set out to identify functionally important DNA:DNA:RNA triplex-forming long non-coding RNAs (lncRNA) in human...

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Literature Corpus work: 3551b75d-3ddb-53d4-9bee-7c4514d6be08
DOI: 10.1101/2021.10.11.463905

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