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HMGB1: The jack‐of‐all‐trades protein is a master DNA repair mechanic

9 Apr 2009

Abstract excerpt

The high mobility group protein B1 (HMGB1) is a highly abundant protein with roles in several cellular processes, including chromatin structure and transcriptional regulation, as well as an extracellular role in inflammation. HMGB1's most thoroughly defined function is as a protein capable of binding specifically to distorted and damaged DNA, and its ability to induce further bending in the DNA once it is bound....

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PMID: 19360789
DOI: 10.1002/mc.20544

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