Article

Genome-wide regulation of CpG methylation by ecCEBPα in acute myeloid leukemia

2021-08-31

Abstract excerpt

<h4>Background: </h4> Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by genetic and epigenetic aberrations that alter the differentiation capacity of myeloid progenitor cells. The transcription factor CEBPα is frequently mutated in AML patients leading to an increase in DNA methylation in many genomic locations. Previously, it has been shown that ecCEBPα (extra coding CEBP α ) - a lncR...

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Literature Corpus work: 305e71b8-81ee-5915-81f9-9e957746b9a2
DOI: 10.12688/f1000research.28146.2

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