Article

Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation

2022-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Local hypoxia occurs in most solid tumors and is associated with aggressive disease and therapy resistance. Widespread changes in gene expression play a critical role in the biological response to hypoxia. However, most research has focused on hypoxia-inducible genes as opposed to those which are decreased in hypoxia. We demonstrate that chromatin accessibility is decreased in hypoxia, predomina...

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Literature Corpus work: fb1541bf-83f2-55a8-981d-3093c5c1b6f4
DOI: 10.1101/2022.04.30.490097

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