Article
Improved RNA-DNA interaction calling suggests RNA-based gene regulation of phenotypic transitions.
Nucleic acids research - 8 Jun 2026
Zehr Simonida, Seredinski Sandra, Pálfi Katalin, Oo James A, Walsh Emma C, Bonetti Alessandro, Leisegang Matthias S, Brandes Ralf P, Schulz Marcel H, Warwick Timothy
Abstract excerpt
Chromatin-localized RNAs play diverse roles in gene regulation and nuclear architecture. Mapping genome-wide RNA-DNA interactions is possible using a variety of molecular methods, including using bridging oligonucleotides to ligate RNA and DNA in proximity. While molecular methods have progressed, a robust computational method for calling biologically meaningful RNA-DNA interactions from these data is lacking....
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