Article

The impact of mutation L138F/L210F on the Orai channel: a molecular dynamics simulation study

2021-06-24

Abstract excerpt

The calcium release-activated calcium (CRAC) channel, composed of the Orai channel and the STIM protein, plays a crucial role in maintaining the Ca 2+ concentration in cells. Previous studies showed that the L138F mutation in the human Orai1 creates a constitutively open channel independent of STIM, causing severe myopathy, but how the L138F mutation activates Orai1 is still unclear. Here, based on the crystal st...

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Literature Corpus work: 354ce191-823f-52bd-85fe-34524f0e1e32
DOI: 10.1101/2021.06.23.449681

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