Article

A human tubular aggregate myopathy mutation unmasks STIM1-independent rapid inactivation of Orai1 channels

2022-08-15

Abstract excerpt

Ca 2+ release-activated Ca 2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca 2+ sensor. A hallmark of CRAC channels is fast Ca 2+ -dependent inactivation (CDI) which provides negative feedback to limit Ca 2+ entry through CRAC channels. Although STIM1 is thought to be essential for mediating CDI, the molecular mechanism...

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Literature Corpus work: 12000e50-d045-5699-8b66-59ff0a4e344e
DOI: 10.1101/2022.08.12.503733

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