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Article

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.

Science signaling - 19 Nov 2019

Schober Romana, Bonhenry Daniel, Lunz Victoria, Zhu Jinhui, Krizova Adela, Frischauf Irene, Fahrner Marc, Zhang MengQi, Waldherr Linda, Schmidt Tony, Derler Isabella, Stathopulos Peter B, Romanin Christoph, Ettrich Rüdiger H, Schindl Rainer

Abstract excerpt

The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. We combined molecular dynamics (MD) simulations with live-cell recordings and determined the sequential Ca2+-dependent conformations of the luminal STIM1 domain upon activation. Furthermore, we...

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Identifiers

PMID: 31744929
DOI: 10.1126/scisignal.aax3194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.PMID 31744929Read ↗

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The TAM-associated STIM1I484R mutation increases ORAI1 channel function due to a reduced STIM1 inactivation break and an absence of microtubule trapping.Semantic proximity Read ↗

Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.Semantic proximity Read ↗

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