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Article

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.

eLife - 20 Feb 2023

Yeung Priscilla S-W, Yamashita Megumi, Prakriya Murali

Abstract excerpt

Ca2+ release-activated Ca2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca2+ sensor. A hallmark of CRAC channels is fast Ca2+-dependent inactivation (CDI) which provides negative feedback to limit Ca2+ entry through CRAC channels. Although STIM1 is thought to be essential for CDI, its molecular mechanism remains largely...

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Identifiers

PMID: 36806330
DOI: 10.7554/eLife.82281
PMCID: PMC9991058

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