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Evolutionary Analysis of Rett Syndrome-Causing Proteins and Their Pathogenic Missense Point Mutations: Structural Order–Disorder, Post-Translational Modifications, Evolutionary Rates, and Interacting Proteins

2019-07-01

Abstract excerpt

Rett syndrome (RTT) is mainly caused by mutations in methyl CpG-binding protein 2, cyclin-dependent kinase-like 5, or forkhead box protein G1. These RTT-causing proteins harbor an intrinsically disordered region (IDR) whose conformation exhibits spatiotemporal heterogeneity, which not only confer versatility to the protein, but also implicates them in diseases. The IDR generally evolves more rapidly than an ordere...

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Literature Corpus work
351cd3f9-8627-5eee-9ff4-60d619dcfd5e
DOI
10.20944/preprints201907.0013.v1
Open publication

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Evolutionary Analysis of Rett Syndrome-Causing Proteins and Their Pathogenic Missense Point Mutations: Structural Order–Disorder, Post-Translational Modifications, Evolutionary Rates, and Interacting ProteinsDOI 10.20944/preprints201907.0013.v1
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