Article

A small number of human lineage mutations regulated RNA-protein binding of conserved genes and promoted human evolution

2023-03-27

Abstract excerpt

Whether human lineage mutations (HLM) have contributed to human evolution via post-transcriptional modification remained unknown. We applied deep learning models Seqweaver to predict how HLM impacts RNA-binding protein affinity (RBP). At the threshold of the top 1% of human common variation, only 0.27% of HLM had large impacts on RBP. These HLMs enriched in a set of conserved genes that are highly expressed in adu...

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Literature Corpus work: f261d2a7-80ef-56e5-aa65-2c4dafd2d669
DOI: 10.1101/2023.03.27.534315

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