Article

Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia

2021-10-10

Abstract excerpt

Genetics have nominated many schizophrenia risk genes that lack functional interpretation. To empower such interpretation, we executed interaction proteomics for six risk genes in human induced neurons and found the resulting protein network to be enriched for common variant risk of schizophrenia in Europeans and East Asians. The network is down-regulated in layer 5/6 cortical neurons of patients and can complemen...

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Literature Corpus work: 64e15e65-9075-5af4-8925-172852f7f136
DOI: 10.1101/2021.10.07.21264568

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