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A Dengue Virus Serotype 1 mRNA-LNP Vaccine Elicits Protective Immune Responses

25 Mar 2021

Abstract excerpt

With 400 million worldwide infections each year, dengue is the most common vector-borne viral disease. Forty percent of the world's population is at risk, with dengue experiencing consistent geographic spread over the years. With no therapeutics available and vaccines performing suboptimally, the need for an effective dengue vaccine is urgent. Here, we develop and characterize a novel mRNA vaccine encoding the...

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PMID: 33762420
DOI: 10.1128/jvi.02482-20

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