Article

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

2021-08-26

Abstract excerpt

<h4>SUMMARY</h4> Although mRNA vaccines prevent COVID-19, variants jeopardize their efficacy as immunity wanes. Here, we assessed the immunogenicity and protective activity of historical (mRNA-1273, designed for Wuhan-1 spike) or modified (mRNA-1273.351, designed for B.1.351 spike) preclinical Moderna mRNA vaccines in 129S2 and K18-hACE2 mice. Immunization with high or low dose formulations of mRNA vaccines induc...

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Literature Corpus work: f09df0fd-4ce7-528a-89b2-28056fbfaf3f
DOI: 10.1101/2021.08.25.457693

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