Article

A mRNA-LNP vaccine against Dengue Virus elicits robust, serotype-specific immunity

2021-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Dengue virus (DENV) is the most common vector-borne viral disease with nearly 400 million worldwide infections each year concentrated in the tropical and subtropical regions of the world. Severe dengue complications are often associated with a secondary heterotypic infection of one of the four circulating serotypes. In this scenario, humoral immune responses targeting cross-reactive, poorly-neut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8564e4f6-c1e3-50bb-bfa4-f0ad22a8f538
DOI: 10.1101/2021.01.05.425517

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A mRNA-LNP vaccine against Dengue Virus elicits robust, serotype-specific immunityDOI 10.1101/2021.01.05.425517Read

A Dengue Virus Serotype 1 mRNA-LNP Vaccine Elicits Protective Immune ResponsesSemantic proximity Read

mRNA-LNP Vaccines Encoding for Dengue Optimized prM/ENV Proteins Induce Protective Immunity without ADESemantic proximity Read

A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic MiceSemantic proximity Read

Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in MiceSemantic proximity Read

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2Semantic proximity Read

An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infectionSemantic proximity Read

mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognitionSemantic proximity Read

Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines: The Superiority of Nucleoside-Modified mRNA Encapsulated in Lipid Nanoparticles Vaccine PlatformSemantic proximity Read

mRNA-delivered neutralizing antibodies confer protection against SARS-CoV-2 variant in the lower and upper respiratory tractSemantic proximity Read

mRNA Vaccines: A Prospective Analysis of Long-term, Multi-target, and Autoimmune DisordersSemantic proximity Read

A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaquesSemantic proximity Read

Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2Semantic proximity Read