Article

A Bistable Mechanism Mediated by Integrins Controls Mechanotaxis of Leukocytes

2018-12-31

Abstract excerpt

The recruitment of leukocytes from blood vessels to inflamed zones is guided by biochemical and mechanical stimuli, with mechanisms only partially deciphered. We studied here the guidance by flow of primary human effector T lymphocytes crawling on substrates coated with ligands of integrins LFA-1 (α L β 2 ) and VLA-4 (α 4 β 1 ), and showed that cells segregated in two populations of opposite orientation for co...

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Literature Corpus work: 8be422ed-815d-5bb5-a03c-815750482b14
DOI: 10.1101/509091

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