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Acquisition of a multibasic cleavage site does not increase MERS-CoV entry into Calu-3 human lung cells

29 Oct 2024

Abstract excerpt

Human-to-human transmission of the highly pathogenic Middle East respiratory syndrome coronavirus (MERS-CoV) is currently inefficient. However, there is concern that the virus might mutate and thereby increase its transmissibility and thus pandemic potential. The pandemic SARS-CoV-2 depends on a highly cleavable furin motif at the S1/S2 site of the viral spike (S) protein for efficient lung cell entry,...

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PMID: 39470207
DOI: 10.1128/jvi.01305-24

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