Article

Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line

2021-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Epidemiological data demonstrate that SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.617.2 are more transmissible and infections are associated with a higher mortality than non-VOC virus infections. Phenotypic properties underlying their enhanced spread in the human population remain unknown. B.1.1.7 virus isolates displayed inferior or equivalent spread in most cell lines and primary cell...

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Literature Corpus work: fa7da8a1-8f34-58f4-9867-c9240984d645
DOI: 10.1101/2021.10.20.465121

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