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The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids

27 Nov 2024

Abstract excerpt

A critical aspect of the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the protease-mediated activation of the viral spike (S) protein. The type II transmembrane serine protease TMPRSS2 is crucial for SARS-CoV-2 infection in lung epithelial Calu-3 cells and murine airways. However, the importance of TMPRSS2 needs to be re-examined because the ability to utilize TMPRSS2 is...

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COVID-19 Clinical Research Studies
Respiratory viral infections research
SARS-CoV-2 and COVID-19 Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39601592
DOI: 10.1128/jvi.01853-24

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