Article

Characterisation of drug-specific T-cell responses in hypersensitive patients and healthy donors

2016-01-01

Abstract excerpt

Drug hypersensitivity reactions represent a significant clinical problem and an impediment to drug development. It is currently impossible develop drugs with no immunological liability; furthermore, it is very difficult to predict which individuals will develop hypersensitivity when exposed to a therapeutic treatment regimen. This is because susceptibility is a function of the chemistry of the drug, the genetic ba...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 34972b58-3721-5f8d-a86b-d7ee52ed73e6
DOI: 10.17638/03004974

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterisation of drug-specific T-cell responses in hypersensitive patients and healthy donorsDOI 10.17638/03004974Read

Characterisation of the B-lymphocyte response in delayed-type piperacillin hypersensitivity reactionsSemantic proximity Read

The phenotype and function of hapten specific T-Cell isolated from hypersensitive patients and healthy human donorsSemantic proximity Read

The role of T-helper 17 and T-helper 22 lymphocytes in beta-lactam hypersensitivitySemantic proximity Read

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.Semantic proximity Read

[Pharmacogenomics of severe drug hypersensitivity reactions--from bench to bedside].Semantic proximity Read

HLA and pharmacogenetics of drug hypersensitivity.Semantic proximity Read

Characterisation of the phenotype and function of drug-responsive T-cells in patients with drug-induced liver injurySemantic proximity Read

Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions.Semantic proximity Read

T Cell–Mediated Hypersensitivity Reactions to DrugsSemantic proximity Read

Phenotypic diversity in delayed drug hypersensitivity: an immunologic explanation.Semantic proximity Read

Activation of CD8+ T-Cell with abacavir and HLA-B*57:01 binding peptides and elimination of T-Cell responses through chemical modificationSemantic proximity Read

Drug hypersensitivity in the fast lane: What clinicians should know about phenotypes, endotypes, and biomarkers.Semantic proximity Read