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Article

Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions.

Allergy - 1 Apr 2020

Naisbitt Dean J, Olsson-Brown Anna, Gibson Andrew, Meng Xiaoli, Ogese Monday O, Tailor Arun, Thomson Paul

Abstract excerpt

Delayed-type, T cell-mediated, drug hypersensitivity reactions are a serious unwanted manifestation of drug exposure that develops in a small percentage of the human population. Drugs and drug metabolites are known to interact directly and indirectly (through irreversible protein binding and processing to the derived adducts) with HLA proteins that present the drug-peptide complex to T cells. Multiple forms of...

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Identifiers

PMID: 31758810
DOI: 10.1111/all.14127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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