Article

Detecting time-varying genetic effects in Alzheimer’s disease using a longitudinal GWAS model

2023-10-17

Abstract excerpt

<h4>Background</h4> The development and progression of Alzheimer’s disease (AD) is a complex process that can change over time, during which genetic influences on phenotypes may also fluctuate. Incorporating longitudinal phenotypes in genome wide association studies (GWAS) could help unmask genetic loci with time-varying effects. In this study, we incorporated a varying coefficient test in a longitudinal GWAS mod...

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Literature Corpus work: 34954372-5a28-54e4-9638-01ba25a78b8a
DOI: 10.1101/2023.10.17.562756

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